Bulk Pure NMN Powder CAS 1094-61-7 Beta Nicotinamide Mononucleotide

Product Description

NMN-SGS TEST REPORT.PDF

Pure NMN Bulk Powder CAS 1094-61-7 Beta Nicotinamide

Product Introduction of NMN Bulk Powder
NMN Bulk Powder is a naturally occurring biologically active nucleotide. it has two irregular forms, alpha and beta; the beta isomer is the active form of NMN with a molecular weight of 334.221 g/mol. since nicotinamide is a vitamin B3, NMN belongs to the group of vitamin B derivatives, which are widely involved in many biochemical reactions in the body and are relevant to immunity and metabolism. It is an intrinsic substance in the body.
It is inherent in the human body and is also found in some fruits and vegetables. NMN is the most direct precursor of NAD+ in the human body and its function is expressed through NAD+, also known as coenzyme I. The full name of NMN is nicotinamide adenine dinucleotide, which is present in every cell and participates in thousands of reactions. The nicotinamide adenine dinucleotide (NAD) molecule plays an important role in a wide range of cellular metabolic reactions and is a vital support for the maintenance of cellular viability.

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Function of NMN Bulk Powder
The decline in NAD during ageing is considered a major cause of disease and disability, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiency, autoimmune inflammatory response dysregulation leading to arthritis, metabolic disorders and cardiovascular disease. Therefore, NMN supplementation increases NAD+ levels in the body, thus delaying, improving and preventing a wide range of phenotypes associated with ageing, or age-induced metabolic disorders and diseases of old age.

1. Alleviates and improves ischaemic heart and brain tissue damage
The therapeutic effect of NMN Bulk Powder on stroke: Stroke, an acute cerebrovascular disease caused by impaired blood circulation in the brain, has a high mortality and disability rate and poses a serious threat to human health. Park et al. found that nicotinamide mononucleotide is a potential anti-stroke therapeutic agent because it improves the bio-energetic metabolism of post-ischaemic tissues. In the case of hemorrhagic brain injury, the increase in nicotinamide mononucleotide may have a strong protective effect on ischemic brain injury. In hemorrhagic brain injury, increasing the level of nicotinamide mononucleotide can reduce the haemoglobin content in infarcted tissue, reduce haemorrhage and oedema, and reduce oxidative toxicity damage in brain tissue caused by oxidative stress.

2. Therapeutic effects of NMN Bulk Powder in cardiac ischaemia-reperfusion

Post-ischaemic reperfusion of the heart is a life-threatening ischaemic injury, a process accompanied by inevitable myocardial cell death and severe organ dysfunction. Ischemic preconditioning (IPC) is an endogenous defence mechanism mediated by the activation of Sirt1 that protects myocardial viability during transient ischaemia-reperfusion. Studies have shown that NMN Bulk Powder can protect the heart by mimicking the protective effects of IPC. NAD+ content in the heart is reduced after ischaemia, exogenous NMN increases NAD+ and NADH content in the heart and reduces infarct size, and data show that the size of NMN reduction in infarct size is positively correlated with Sirt1 expression levels. Furthermore, Nampt expression levels in the heart are downregulated under pathological conditions such as ischaemia, ischaemia-reperfusion and pressure overload, which in turn affect NAD+ biosynthesis and disrupt the regulatory mechanisms of Sirt1 activity, leading to apoptosis and dysregulated cardiac compensation in pressure overloaded mice. It was shown that in mice, a model of heart failure, NMN treatment restored NAD+ levels in cardiomyocytes and increased the deacetylase activity of Sirt1 and the expression levels of genes related to mitomycin function.