Nicotinamide Mononucleotide Pure NMN Powder In Bulk For Eyesight

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NMN-SGS TEST REPORT.PDF

Nicotinamide Mononucleotide NMN Powder In Bulk For Eyesight

Product Function of Nicotinamide Mononucleotide NMN Powder
1. Nicotinamide Mononucleotide NMN Powder Delays Ageing: Nicotinamide Mononucleotide NMN Powder was found to significantly improve age-related physiological decline in mice, such as inhibition of age-related weight gain, enhancement of energy metabolism, improvement of insulin sensitivity and It also prevented age-related gene expression changes in a tissue-specific manner and enhanced mitochondrial oxidative metabolism in skeletal muscle, mediating, at least in part, its anti-ageing effects.

2. Nicotinamide Mononucleotide NMN Powder for degenerative vision diseases: The causes of visual impairment are complex and varied, but photoreceptor death is the endpoint of many blinding diseases. Photoreceptors form an important part of the neurosensory retina, which is one of the most metabolically active tissues in the body. Studies have shown that several mouse models of retinal dysfunction (light-induced degeneration, streptozotocin-induced diabetic retinopathy and age-related retinal dysfunction) exhibit early retinal NAD+ deficiency, which not only performs coenzyme functions in all steps of the tricarboxylic acid cycle and glycolysis, but also maintains optimal Sirt3 activity.

Sirt3 and Sirt5 play important roles in retinal homeostasis, and NAD+ deficiency causes multiple dysfunctions) and the inability to respond appropriately to metabolic stress, which ultimately leads to photoreceptor death and retinal degeneration. The investigators found that supplementation with Nicotinamide Mononucleotide NMN Powder restored normal basal glycolytic function, mitochondrial function and the ability to adapt to metabolic stress in mice, reduced photoreceptor cell death and significantly improved dark vision and retinal function. These findings support the potential use of the NAD+ intermediate nicotinamide mononucleotide for the treatment of retinal degenerative diseases, identifying a unified therapeutic target for ocular degenerative diseases and providing a powerful therapeutic pathway. As it can be implemented for multiple diseases with multiple pathogenic mechanisms, the impact of this therapeutic strategy, once successfully implemented, will be far-reaching.

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Product Application of Nicotinamide Mononucleotide NMN Powder
NMN is found in a wide range of natural foods, including vegetables, fungi, meat and shrimps, and has also been found in human and donkey milk by novel enzyme coupling techniques, with higher levels in human milk. Processing characterisation studies have found that NMN is stable in water or milk when treated at 75°C for 5 min, and loses about 20% of its activity after 5 min at 95°C, indicating the theoretical feasibility of adding NMN to pasteurised milk.

Other oral experiments have shown that NMN can be rapidly absorbed within 30 min of administration of lower concentrations, efficiently transported into the circulation and immediately converted to NAD+ in the main metabolic tissues. In addition, NMN did not show any significant toxicity or lethality or serious side effects in a dry period lasting 12 months and has a high food safety profile.

Currently, Megumi in Japan has developed a food combination of NMN and resveratrol. Resveratrol is a natural polyphenolic compound that acts as an estrogen and has antioxidant, antibacterial, tyrosinase inhibiting activity, improving metabolic syndrome and extending life expectancy. The food composition has been shown to reduce the total cholesterol level in the blood and reduce the incidence of myocardial infarction; to reduce the LDL level; to reduce the uric acid level in the blood and the level of neutral fats such as triglycerides. Functional foods with NMN as the active ingredient have great potential for development, but data on NMN in human trials are scarce and the maximum tolerated dose and duration of tolerance in humans are rarely reported, therefore, the safety of NMN in humans still needs to be further explored.

In health food, NMN is used as the active ingredient in nutraceuticals to improve atherosclerosis and cardiovascular diseases, in nutraceuticals to improve Parkinson's disease and in anti-ageing nutraceuticals. With further revelations on the safety of NMN, it is believed that more food or health products with NMN will benefit human life in the future.