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API Citicoline Sodium Pharmaceutical Ingredients CAS 33818-15-4

Minimum Order Quantity : 1kg, 25kg/drum, sample is available Packaging Details : Vacuum Aluminum Foil Bag; Fiber Drum for 25kg with inside double layer food grade poly bag
Delivery Time : 5-7 working days Payment Terms : T/T, Western Union, Pay Pal, Alibaba Assurance Account
Place of Origin: China Brand Name: Xi'an Le-Nutra
Certification: FDA,ISO9001,HACCP,HALAL,KOSHER etc

Detail Information

Other Name: CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE Grade: Pharmaceutical Grade
Citicoline Sodium: ≥98% Appearance: White Crystals Or Crytalline Powder, Odorless
CAS No.: 33818-15-4 USE: After Injection Of Sodium Cytophosphatidylcholine Injection, It Can Rapidly Enter The Blood, And Some Of It Can Enter The Brain Tissue Through The Blood-brain Barrier. The Choline Part Becomes A Good Methylation Donor In The Body And Can Have Transmethylat
Function: CAcute Craniocerebral Trauma And Post-brain Surgery Disorders Of Consciousness, Gradual Restoration Of Limb Function In Hemiplegia Due To Stroke, Also For Functional And Consciousness Disorders Due To Other Acute Injuries To The Central Nervous System, Als Shelf Life: 2 Years
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Citicoline Sodium Pharmaceutical Ingredients

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API Pharmaceutical Ingredients

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CAS 33818-15-4 Pharmaceutical Ingredients

Product Description

Procuct Introduction of API Powder

Cytosine, the main component of cell membrane phospholipids, is a complex organic molecule consisting of ribose, pyrophosphate, cytosine and choline. Cytosine is water soluble and its oral bioavailability is greater than 90%. Cytosine has no mitogenic or chemotactic effect on hCMEC/D3. However, it significantly enhances the chemical book of wound healing, globule germination and strongly induces the formation of endothelial tubular structures in the basement membrane stroma. Cytocholine induces the expression of phosphorylated ERK1/2. It protects hCMEC/D3 from cell damage/apoptosis. Cytidine phosphorylcholine induces angiogenesis and enhances the survival of human brain microvascular endothelial cells via p-ERK1/2 and IRS-1 related pathways.

Bioactivity​ of API Powder

Citicoline (CDP-choline) is an essential intermediate in the synthesis of lecithin, the main phospholipid of cell membranes. It increases plasma adrenocorticotropic hormone levels and enhances serum thyrotropin levels.

In vitro studies.

API Citicoline Sodium Pharmaceutical Ingredients CAS 33818-15-4 0

Certificate of Analysis

Product Name Citicoline Sodium
CAS No. 33818-15-4
Analysis Standard ChP 2020 Part II
Grade Pharmaceutical grade
Item Standard Test Result
Citicoline Sodium ≥98% 100.2%
Appearance White crystals or crystalline powder, odorless Complies
Ammonium ≤0.05% Complies
Phosphate ≤0.1% Complies
Iron ≤0.01% Complies
Chloride ≤0.05% Complies
PH 6.0-7.5 6.6
Solubility Soluble in water, insoluble in ethanol, insoluble in acetone  
Loss on Drying ≤6% 1.6%
Heavy Metal ≤5ppm Complies
Arsenic ≤0.0001% Complies
Related substance
5’-CMP ≤0.3% 0.023%
Other single impurity ≤0.2%  
Other total impurities ≤0.7% 0.011%
Residual solvents
Methanol ≤0.3% Not detected
Ethanol ≤0.5% 0.003%
Acetone ≤0.5% Not detected
Bacterial endotoxins <0.3EU/mg Complies

Drugs for the central nervous system (API Powder)

Coenzyme. Used for impaired consciousness after acute craniocerebral trauma and brain surgery. Disorders of consciousness after acute craniocerebral trauma and brain surgery, for hemiplegia due to stroke with gradual restoration of chemistry book limb function, also for functional and consciousness disorders due to other acute central nervous system injuries, also for ischaemic cerebrovascular disease and vascular dementia.

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