Contact Us

Phone Number : 86-15209233790

WhatsApp : +8615209233790

Free call

Anti Aging Cotinus Coggygria Fisetin Powder CAS 528-48-3

Minimum Order Quantity : 1kg, 25kg/drum, sample is available Price : Negotiable
Packaging Details : Vacuum Aluminum Foil Bag; Fiber Drum for 25kg with inside double layer food grade poly bag Delivery Time : 5-7 working days
Payment Terms : T/T, Western Union, Pay Pal, Alibaba Assurance Account Supply Ability : 500kg/month
Place of Origin: China Brand Name: Xi'an Le-Nutra
Certification: FDA,ISO9001,HACCP,HALAL,KOSHER etc Model Number: Cotinus Coggygria Extract

Detail Information

Product Name: Cotinus Coggygria Fisetin Appearance: Yellow Needle Crystal
CAS: 528-48-3 Specification: 50%, 80%, 85%, 96%
Botanical Source: Cotinus Coggygria Scop Used Parts: Twigs (peeled)
Molecular Formula: C15H10O6 Solubility: Soluble In Ethanol, Acetone And Acetic Acid. Practically Insoluble In Water, Ether, Benzene, Chloroform And Petroleum Ether
Grade: Pharmaceutical Grade, Food Grade Mainly Use: Anti-tumour, Inhibits Tumour Cells, Anti-depressant, Improves Immune Cell Activity, Improves Long-term Memory
High Light:

Cotinus Coggygria Fisetin Powder


CAS 528-48-3 Fisetin Powder


Anti Aging Cotinus Coggygria Powder

Product Description

Anti Aging Cotinus Coggygria Fisetin Powder CAS 528-48-3

Product Introduction of Cotinus Coggygria Fisetin
Cotinus Coggygria Fisetin, being a flavonoid with inherent antioxidant properties, not only has direct antioxidant activity but also increases the level of the main intracellular antioxidant glutathione. Even under oxidative stress, Cotinus Coggygria Fisetin maintains mitochondrial function very well and even the very fragile neuronal cells are well protected.

In addition to its antioxidant properties, Cotinus Coggygria Fisetin also has an anti-inflammatory effect, as it inhibits the NF-κB pro-inflammatory signalling pathway by activating the β-catenin protein and silencing TLR4 expression, thereby down-regulating the release of inflammatory cytokines.

Anti Aging Cotinus Coggygria Fisetin Powder CAS 528-48-3 0

Certificate of Analysis

Physical Data
Appearance Fine Powder Organoleptic Conform
Color Yellow Organoleptic Conform
Odor & taste Characteristic Organoleptic Conform
Analytical Quality
Identification Identical to R.S. Sample HPLC Conform
Sieve analysis 100% through 80 mesh US Screen Conform
Fisetin ≥98.0% HPLC


(Area normalisation method)

Loss on Drying ≤2.0% 5g/100℃/2.5hrs 0.64%
Residual on ignition ≤1.0% 2g/535℃/3hrs 0.79%
Heavy metals
Lead(Pb) ≤2.0 ppm Atomic Absorption Conform
Arsenic(As) ≤2.0 ppm Atomic Absorption Conform
Cadmium(Cd) ≤1.0 ppm Atomic Absorption Conform
Mercury(Hg) ≤0.5 ppm Atomic Absorption Conform
Total Plate Count ≤1000cfu/g CP2015 Conform
Yeast & Mold ≤100cfu/g CP2015 Conform
E.Coli Negative CP2015 Negative
Salmonella Negative CP2015 Negative
AflatoxinB1 ≤5.0ppb CP2015 Conform
General Status
Irradiation Non-Irradiation
GMO/BSE Status No Genetically modified organism, Free of BSE
Storage Store in a well-closed container away from moisture, light and oxygen.


Product Function of Cotinus Coggygria Fisetin
1. In the early stages of a tumour, Cotinus Coggygria Fisetin interferes with chromosome segregation and promotes DNA double-strand breaks, thereby reducing its rate of proliferation. During the rapid growth phase of a tumour, laccasein can also reduce angiogenesis and cut off the source of nutrition to the tumour by inhibiting uPA (urokinase fibrinogen activator). In the advanced stages of tumour development, when tumours may metastasise, laccasein prevents the degradation of the ECM protein barrier by inhibiting MMP-1, a key target, thus preventing tumour cells from entering the bloodstream and inhibiting metastasis.

2. Cotinus Coggygria Fisetin slows down ageing. Like other organs, brain function also ages with age. A key mechanism leading to ageing is cellular senescence, in which DNA damage, mitochondrial dysfunction or the accumulation of other cellular stress factors cause cells to enter a state of replicative arrest and resistance to apoptosis. Senescent cells are rare in young individuals, but increase with age in a wide range of tissues. Senescent cells accumulate a great deal of damage but do not undergo apoptosis, instead continuing to cause chronic inflammation and tissue damage both locally and systemically.
Animal studies have shown that transplanting senescent cells into young mice induces a range of age-related diseases, while removing senescent cells from aged mice improves the health of multiple organ systems and extends life span.

Anti Aging Cotinus Coggygria Fisetin Powder CAS 528-48-3 1

Anti Aging Mechanism of Cotinus Coggygria Fisetin
Cotinus Coggygria Fisetin relies on two main points for its powerful anti-aging ability, one as a calorie-limiting mimetic and the other as a Senolytics substance.

Caloric Restriction Mimetics
Caloric restriction (CR), although effective in slowing down the ageing process, can be painful and slow to implement, which is a deterrent for most people, but caloric restriction mimetics (CRMs) are a perfect solution as they can mimic CR and activate the corresponding signalling pathways without having to reduce caloric intake.
As a calorie restriction mimetic, laccasein induces autophagy by upregulating the expression of SIRT1 in the Sirtuins family, which in turn inhibits mTOR. Unlike other calorie restriction mimetics such as metformin, laccasein is tissue specific and has a better effect on brain cells in promoting autophagy.

Senolytics substances
Senolytics refers to the targeted removal of senescent cells. As a person ages, senescent cells accumulate and secrete large amounts of SASP (senescence-associated secretory phenotypes) that contribute to the senescence of surrounding normal cells, thereby accelerating the ageing of the body.
A 2018 study showed that laccasein was the most effective in scavenging senescent cells among the 10 flavonoids available at the time, surpassing resveratrol, curcumin and catechin, making it a priority for scientists to study. Another study showed that laccasein reduced the mortality rate of senescent cells from nearly 100% to 50% in aged mice with neocoron.


You Might Be Into These
Get in touch with us

Enter Your Message