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CAS 72-10-4 99% Medical Sulfathiazole Powder C9H9N3O2S2 USP

Minimum Order Quantity : 1kg, 25kg/drum, sample is available Packaging Details : Vacuum Aluminum Foil Bag; Fiber Drum for 25kg with inside double layer food grade poly bag
Delivery Time : 5-7 working days Payment Terms : T/T, Western Union, Pay Pal, Alibaba Assurance Account
Place of Origin: China Brand Name: Xi'an Le-Nutra
Certification: FDA,ISO9001,HACCP,HALAL,KOSHER etc

Detail Information

CAS NO: 72-14-0 Appearance: White Crystalline Powder
Molecular Formula: C9H9N3O2S2 EINECS NO.: 200-771-5
Analysis According: USP Uses: Mainly Used To Treat Infections Such As Streptococcus Haemolyticus, Meningococcus And Pneumococcus. Eliminated Due To Its High Toxic Reaction.
Product Application: Medical Raw Materials; Sulfathiazole Ointment Cautions: Contraindicated In Patients Allergic To Sulfonamide And In Patients With Severe Liver And Kidney Disease.
High Light:

99% Sulfathiazole Powder

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CAS 72-10-4 Sulfathiazole Powder

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99% Medical Sulfathiazole Powder

Product Description

Product introduction of API Powder

Sulfathiazole powder 99% is an organosulphur compound and is a short-acting Sulphonamide antibiotic.

1. Characteristic

It is white or light yellow crystalline granules or powder, odourless and tasteless. It is stable in air and gradually changes colour when exposed to light.

2. Dissolution

Very slightly soluble in water, but easily soluble in sodium hydroxide test solution, also soluble in dilute hydrochloric acid. The colour darkens in contact with light and should be kept airtight in a light-proof container.

3. Uses

Mainly used to treat infections such as Streptococcus haemolyticus, Meningococcus and Pneumococcus. Eliminated due to its high toxic reaction.

CAS 72-10-4 99% Medical Sulfathiazole Powder C9H9N3O2S2 USP 0

4. Preparation or source

May be prepared by condensation of 2-aminothiazole with p-nitrobenzenesulfonyl chloride followed by reduction.

 

Biochemical mechanism of API Powder

A Sulphonamide antibiotic that blocks the synthesis of dihydrofolate by inhibiting dihydrofolate synthase. Antibiotics.

Mode of action: Inhibition of folic acid synthesis in prokaryotes.

Antimicrobial spectrum: Gram-positive bacteria, Gram-negative bacteria, Chlamydia Mechanism of resistance: alteration of dihydrofolate synthase or alternative pathways of folate synthesis.

 

Certificate of Analysis

Product Name Sulfathiazole CAS NO. 72-14-0
Molecular Weight C9H9N302S2 Manufacture Date Sep, 23th, 2021
Analysis According USP Expire Date Sep, 22th, 2023

 

Item Standard Test Result
Assay 97.0%-100.0% 99.0%
Physical&Chemical  
Appearance White Crystalline Powder Complies
Chromatographic purity Conform Complies
Loss on drying ≤0.5% 0.3%
Related Substances ≤0.5% 0.23%
Selenium ≤30ppm 21ppm

Functions of API Powder

 

Sulfathiazole Powder 99% has the effect of inhibiting bacterial growth and reproduction by inhibiting the synthesis of folic acid and is a broad-spectrum antibacterial agent, which is one of the stronger antibacterial effects of sulfa drugs.

Sulfathiazole ointment can inhibit the dihydrofolate synthase of bacteria, hinder the synthesis of folic acid of bacteria and inhibit the growth and reproduction of bacteria. It has antibacterial effects on Streptococcus haemolyticus, Streptococcus pneumoniae, Streptococcus gonorrhoeae, Staphylococcus, Meningococcus, Escherichia coli and Bacillus dysenteriae.

 

Sulfathiazole API powder is easily absorbed internally, excreted slowly and the blood concentration can easily reach the effective level. Due to the low binding rate to plasma proteins (17% in dogs), it can easily pass the blood-brain barrier, so it can enter the cerebrospinal fluid to reach a high drug concentration, and its half-life in the body is 9.84h in dogs.

It is more effective against Streptococcus haemolyticus, S. pneumoniae, Salmonella and E. coli, but less effective against Staphylococcus.

 

Sulfathiazole pharm grade has a high serum protein binding and acetylation rate, and the solubility of acetylated sulphathiazole in urine is low, so it is easy to cause crystalluria and haematuria, other side effects are also more, excretion is fast, is a short-acting sulphonamide. It is a short-acting sulphonamide. Due to its low cost and availability, its antibacterial effect and efficacy are still good and it is still used in veterinary practice.

 

Product Application of API Powder

-Medical raw materials

-Sulfathiazole Ointment

CAS 72-10-4 99% Medical Sulfathiazole Powder C9H9N3O2S2 USP 1

 

Cautions of API Powder

1. Contraindicated in patients allergic to sulfonamide and in patients with severe liver and kidney disease.

2. Occasionally haemolytic anaemia, aplastic anaemia, granulocytopenia and allergic purpura, exfoliative dermatitis may occur in severe cases.

3. Adverse reactions such as nausea, vomiting, dizziness, skin rash and drug fever.

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