Product Description

Product introduction

Naringin powder 98% CAS 10236-47-2 also known as Naringin, citrus and isohesperidin, is a dihydroflavone compound isolated from pomelo peel. It has a bitter taste and naturally exists in the peel and pulp of grapefruit, orange and orange of rutus family. It is also one of the main effective ingredients in Traditional Chinese medicine such as bone shushu, Aurantii, Fructus aurantii and Tangerine. The content of naringin in various plants varies greatly with variety and origin, and immature fruits usually have higher content of naringin.

 

 

Naringin powder 98% CAS 10236-47-2 has many biological activities, including antioxidant activity. Inhibition of mutagenicity of heterocyclic amines; Anticancer effect; Prevention and treatment of gastric ulcer; It can inhibit staphylococcus aureus, Salmonella, Shigella, Escherichia coli and some fungi. Anti-inflammatory effect; Antagonism against certain poisons; Lowering blood lipids and cholesterol; Antispasmolysis and analgesia; Improve microcirculation and cellular function of cartilage tissue; Reduce capillary permeability and bone joint lesion rate, promote the absorption and metabolism of some drugs in the human body.

Physical and chemical properties

1. Generic name: Naringin powder 98% CAS 10236-47-2

 

 

2. English name: Naringin powder 98% CAS 10236-47-2

 

 

3. Trade name: naringin, citrus side, isohesperidin, citrine

 

 

4. Molecular formula: C27H32O14

 

 

5. Cas No: 10236-47-2

 

 

6. Molecular weight: 580.53 Density: 1.66± 0.1g /cm3

 

 

7. Plant source: Citrus Paradisi Macfadyen fruit

 

 

8. Solubility: 1g soluble in 1000mL water, up to 10% at 75℃, soluble in methanol, acetone, ethanol, thermoacetic acid, dilute alkali solution, pyridine, formamide and dimethyl formamide, and hot water, insoluble in petroleum ether, benzene, diethyl ether, hexane and chloroform.

Certificate of analysis

Product Name:	Naringenin Powder 98%	Country Of Origin:	China
Batch Number:	LEN-20210923	Manufacture Date:	Sep, 23th, 2021
Quantity:	300kgs	Expiry Date:	Sep, 22th, 2023

ITEM	SPECIFICATION	RESULTS	Test Method
Appearance	Light yellow or off-white Powder	Conform	Visual
Identification	The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution	Conform	EP.2.2.29
SPECIFIC TESTS
Loss on drying	≤5.0%	0.16%	EP.2.5.12
Sulfated ash	≤0.5%	0.04%	EP.2.4.14
Heavy Metals	≤10ppm	Conform	BS EN ISO 17294-2 2016
As	≤1.5ppm	Conform	BS EN ISO 17294-2 2016
Pb	≤0.5ppm	Conform	BS EN ISO 17294-2 2016
Hg	≤1.5ppm	Conform	BS EN 13806:2002
Cd	≤0.5ppm	98.54%	BS EN ISO 17294-2 2016
Assay(anhydrous substance)	≥90.0% and ≤100.5%	3266ppm	EP.2.2.29
Ethanol	≤5000ppm	0.36%	EP.2.2.24
Microbil Limit
TAMC	≤5000cfu/g	200cfu/g	EP.2.6.12 EP.2.6.13
TYMC	≤500cfu/g	30cfu/g
E.Coliform	Negative in 1g	Conform

Pharmacological effects

1. Naringin powder 98% CAS 10236-47-2 has anti-virus, anti-mutation, anti-allergy, anti-ulcer, analgesic and analgesic activities, can reduce blood cholesterol, reduce thrombosis, improve local microcirculation and nutrition supply, can be used for production and prevention of cardiovascular and cerebrovascular diseases.

2. Naringin powder 98% CAS 10236-47-2 hesperidin belongs to vitamin drugs, can reduce the brittleness of capillary, protect capillaries, prevent microvascular rupture and bleeding. For the adjuvant treatment of hypertension.

Funcation 

1. The antibacterial

Naringin powder 98% CAS 10236-47-2 has strong antibacterial effect on staphylococcus aureus, colon, dysentery and typhoid bacillus. Naringin also has fungal effects, with 1000ppm applied to rice reducing magnaporthe grisea infection by 40-90% and showing no toxicity to humans or livestock.

2. The anti-inflammatory

Intraperitoneal injection of 20mg/kg per day significantly inhibited the inflammatory process induced by implantation of wool balls. Galati et al. found through mouse ear slice experiment that naringin in all dose groups had anti-inflammatory effect, and the anti-inflammatory effect increased with the increase of dose.

3. The immune regulation

Naringin powder 98% CAS 10236-47-2 maintains a moderate balance of oxidative stress at certain times and in certain regions of the cell by regulating the flow of electrons within the mitochondria. Therefore, the immunomodulatory function of naringin is different from that of traditional immune enhancers or immunosuppressants. Its characteristic is that it can restore the unbalanced immune state (pathological state) to the normal immune balance state (physiological state), instead of enhancing or suppressing the immune response unidirectional.

4. Menstrual regulation for women

Naringin powder 98% CAS 10236-47-2 has the activity similar to non-steroidal anti-inflammatory drugs, and can reduce the synthesis of prostaglandin PGE2 by inhibiting cyclooxygenase COX, thus playing the role of antipyretic, analgesic and inflammatory relief.

Based on the estrogen-like effects of naringin, naringin can be used as a replacement therapy for estrogen in postmenopausal women to avoid serious adverse reactions caused by long-term estrogen use.

5. Impact on obesity

Naringin powder 98% CAS 10236-47-2 has obvious therapeutic effect on hyperlipidemia and obesity.

Naringin powder 98% CAS 10236-47-2 can significantly improve the high plasma cholesterol concentration, TG (triglyceride) concentration and free fatty acid concentration in obese rats. It was found that naringin can reduce blood lipid levels by up-regulating peroxide-proliferator-activated receptor δ in monocytes in high-lipid model rats.

In clinical trials, people with hypercholesterolemia took a 400mg naringin capsule daily for eight weeks. Plasma TC and LOW density lipoprotein cholesterol (LDL-C) concentrations decreased, while TG and HIGH density lipoprotein cholesterol (HDL-C) concentrations did not change significantly.

 

 

 

 

Useages

 

Naringin has anti-inflammatory, analgesic, antiviral, bacteriostasis and ocular aldose reductase inhibition effects. The derivative of neohesperidin, dihydrochalidone neohesperidin produced by hydrotreating, is 1500 times sweeter than sucrose.

1. bitter agent. The sweetness of naringin dihydrochalcone obtained by hydrolyzing and hydrogenation of naringin was 150 times that of sucrose.

2. Naringin powder 98%  has obvious anti-inflammatory effect, can reduce the viscosity of blood, reduce the formation of thrombosis, and has analgesic, sedative and increase the bile secretion of experimental animals.

3. Natural pigments, flavor modifiers and bitters can be used in the production of food and beverage, and can also be used as raw materials for the synthesis of high sweetness, non-toxic and low energy new sweeteners dihydrochalcone and neohesperidin dihydrochalcone.