Berberine N-HYDRATE Goldthread Root Herbal Extract Powder Cas 633-65-8

Product Description

Product Information of Herbal Extract Powder

As a compound with broad application prospects, berberine has made great progress in the extraction process in recent years, and there are more and more extraction methods. In addition to the commonly used extraction methods such as acid-water and alkaline-water, new extraction methods with low pollution and high extraction efficiency have emerged, such as supercritical fluid extraction, enzyme method and double aqueous phase extraction method. Berberine has been used clinically for its functions of clearing heat and detoxifying and antibacterial, and has a variety of pharmacological activities such as good anti-dysentery, anti-infectious protozoa and anti-tumour, hypoglycaemia, regulation of blood lipids, hypotension and anti-arrhythmia.

Its remarkable anti-heart failure, anti-arrhythmic, cholesterol-lowering, anti-vascular smooth muscle proliferation, improving insulin resistance, anti-platelet and other applications in cardiovascular and neurological diseases are gaining attention. In addition, berberine's role in agriculture as an antibacterial and insecticide, and in livestock as an anti-disease and yield enhancer, has also attracted much attention in agro-pastoral applications.

Technical Date Sheet

Pharmacological Action of Herbal Extract Powder

1. Bacteriostatic effect

Berberine has broad-spectrum antibacterial activity, with strong antibacterial activity against Staphylococcus epidermidis, Neisseria meningitidis and Escherichia coli, and unique efficacy against Cholera, Giardia, Shigella and Salmonella. Berberine can compete with the bacterial enzyme pyridoxal phosphate for the enzyme proteins on tyrosine decarboxylase and tryptophanase, resulting in irreversible bacterial inhibition; inhibit the oxidation of pyruvate in the process of sugar metabolism in bacteria, so that the use of vitamin AT and nicotinamide by bacteria is restricted to achieve the inhibition effect; inhibit the synthesis of NDA, RNA, protein and lipid in bacteria, thus interfering with bacterial reproduction.

2. Anti-inflammatory effect

Berberine inhibits acute and chronic inflammation and has a significant inhibitory effect on delayed hypersensitivity reactions, experimental ulcerative colitis and experimental autoimmune tubulointerstitial nephritis. It has an anti-acute inflammatory effect both orally and by injection.

3. Antiviral effects

Berberine inhibits CEM-GFP cells in HIV replication, inhibits viral protein transport/maturation of post-translational viruses, inhibits TNF-α and PGE2 production, and inhibits the growth of influenza A (H1N1) strains in a variety of mammalian cell types2.

4. Treatment of diabetes and its complications

Berberine can lower fasting blood sugar, improve glucose tolerance, increase insulin sensitivity and insulin secretion, improve insulin signaling in muscle tissues, increase the expression level of p85 subunit of PI-3K and GLUT4 protein in skeletal muscle tissues, and treat type 2 diabetes, as well as improve retinal, peripheral nervous system, cardiac and renal lesions to varying degrees, thereby delaying the progression of complications.

5. Anti-tumour

Berberine inhibits tumour cell proliferation by interfering with the formation of tumour-associated macrophages, affecting the growth cycle of tumour cells, inhibiting the activity of transcription factor AP-1, inhibiting the adhesion of tumour cells, inhibiting tumour cell invasion and metastasis, regulating pro- and anti-apoptotic genes, and regulating mitochondrial transmembrane potential to induce tumour cell apoptosis. It can also reduce the glucose uptake ability of HT29 cells, decrease the expression of glucose transporter protein (GLUT1) in HT29 cells to inhibit the proliferation of human colon cancer HT29 cells, reduce the number of M2 macrophage markers CD +68 and CD +206 macrophages in subcutaneous transplanted tumor tissues, and inhibit the formation of tumor-associated macrophages to exert anti-tumor effects.

6. Treatment of intestinal diseases

Berberine reduced colonic injury in mice with colitis, increased the levels of caspase-12, caspase-3 and GRP78 mRNA, which are down-regulated ER stress markers in mouse colonic epithelial cells (IEC), reduced the inflammatory response in mice, protected the intestine, reduced the expression of pro-inflammatory factors in the early stages of abdominal infection, reduced the intensity of the inflammatory response, slowed down the loss of tight junction proteins and slowed down the loss of intestinal epithelial cells. The intestinal barrier was protected by reducing the expression of pro-inflammatory factors, decreasing the intensity of the inflammatory response and slowing down the disappearance of tight junction proteins and the death of intestinal epithelial cells.