Light Yellow Herbal Extract Powder Berberine Coptis Root Extract

Product Description

Product Information of Herbal Extract Powder

Berberine, being a compound with promising applications, has gained significant progress in the extraction process recently, and more and more extraction methods have been developed. Besides the commonly used extraction methods such as acid-water method and alkaline-water method, new extraction methods with low pollution and high extraction efficiency such as supercritical fluid extraction method, enzyme method and double aqueous phase extraction method have also emerged. Berberine has clinical functions of purging heat and detoxifying and antibacterial, with good anti-dysentery, anti-infective protozoa and anti-tumour, hypoglycaemic, lipid regulating, hypotensive and anti-arrhythmic pharmacological activities.

There is growing interest in its remarkable anti-heart failure, anti-arrhythmic, hypocholesterolemic, anti-vascular smooth muscle proliferation, improvement of insulin resistance and anti-platelet applications in cardiovascular and neurological diseases. In its application in agriculture as an antibacterial and insecticide, and in animal husbandry as an anti-disease and yield enhancer, berberine has also attracted much attention.

Technical Date Sheet

Pharmacological Action of Herbal Extract Powder

1. Bacteriostatic effect

Berberine possesses broad spectrum antibacterial activity, showing strong antibacterial activity against Staphylococcus epidermidis, Neisseria meningitidis and Escherichia coli, and has distinctive efficacy against Cholera, Giardia, Shigella and Salmonella. Berberine competes with bacterial pyridoxal phosphate enzymes for enzyme proteins on tyrosine decarboxylase and tryptophanase, resulting in irreversible bacterial inhibition; inhibits the oxidation of pyruvate during bacterial sugar metabolism, limiting the use of vitamin AT and nicotinamide by bacteria to achieve bacterial inhibition; inhibits the synthesis of NDA, RNA, proteins and lipids in bacteria, thus interfering with bacterial reproduction.

2. Anti-inflammatory effect

Berberine can inhibit both acute and chronic inflammation and shows a significant inhibitory effect on delayed hypersensitivity reactions, experimental ulcerative colitis and experimental autoimmune tubulointerstitial nephritis. Both orally and by injection it has an anti-acute inflammatory effect.

3. Antiviral effects

Berberine inhibits CEM-GFP cells in HIV replication, inhibits viral protein transport/maturation of post-translational viruses, inhibits TNF-α and PGE2 production, and inhibits the growth of influenza A (H1N1) strains in a variety of mammalian cell types2.

4. Treatment of diabetes and its complications

Berberine may reduce fasting blood glucose, affect glucose tolerance, improve insulin sensitivity and insulin secretion, enhance insulin signaling in muscle tissue, and increase the expression levels of the p85 subunit of PI-3K and GLUT4 protein in skeletal muscle tissue for the treatment of type 2 diabetes, and may also improve retinal, peripheral nervous system, cardiac and renal lesions to varying degrees, which may slow down the development of complications.

5. Anti-tumour

Berberine inhibits tumour cell proliferation by interfering with the formation of tumour-associated macrophages, affecting the growth cycle of tumour cells, inhibiting the activity of transcription factor AP-1, inhibiting the adhesion of tumour cells, inhibiting tumour cell invasion and metastasis, regulating pro- and anti-apoptotic genes, and regulating mitochondrial transmembrane potential to induce tumour cell apoptosis. It can also reduce the glucose uptake ability of HT29 cells, decrease the expression of glucose transporter protein (GLUT1) in HT29 cells to inhibit the proliferation of human colon cancer HT29 cells, reduce the number of M2 macrophage markers CD +68 and CD +206 macrophages in subcutaneous transplanted tumor tissues, and inhibit the formation of tumor-associated macrophages to exert anti-tumor effects.

6. Treatment of intestinal diseases

Berberine decreased the colonic damage in mice with colitis, raised the levels of downregulated ER stress markers caspase-12, caspase-3 and GRP78 mRNA in mouse colonic epithelial cells (IEC), decreasing the inflammatory response in mice, protecting the intestine, lowering the expression of pro-inflammatory factors in the early stages of abdominal infection, diminishing the intensity of the inflammatory response, slows the tight loss of linker proteins and slowed the loss of intestinal epithelial cells. Preservation of the intestinal barrier by reducing the expression of pro-inflammatory factors, decreasing the intensity of the inflammatory response, which slows the disappearance of tight junction proteins and the death of intestinal epithelial cells.