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CAS 446-72-0 Genistein Herbal Extract Powder For Cardiovascular Diseases

Minimum Order Quantity : 1kg, 25kg/drum, sample is available Packaging Details : Vacuum Aluminum Foil Bag; Fiber Drum for 25kg with inside double layer food grade poly bag
Delivery Time : 5-7 working days Payment Terms : T/T, Western Union, Pay Pal, Alibaba Assurance Account
Place of Origin: China Brand Name: Le-nutra
Certification: FDA,ISO9001,HACCP,HALAL,KOSHER etc

Detail Information

CAS No.: 84696-21-9 Extraced From: Parochetus Communis Buch.-Ham Ex D. Don Prodr.
Active Ingredients: Genistein 98% Other Name: 4',5,7-TRIHYDROXYISOFLAVONE
Appearance: Off-white Fine Powder Pharmacological Action: Cardiovascular Diseases Cranial Nerves
Function: Prevent Alzheimer's Disease Beauty, Anti-aging Effect Shelf Life: 2 Years Proper Storage
Storage: Store In Cool And Dry Places. Keep Away From Strong Light And Heat.
High Light:

Genistein Herbal Extract Powder

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CAS 446-72-0 Herbal Extract Powder

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Cardiovascular Diseases Genistein Powder

Product Description

Product Introduction of Herbal Extract Powder

Genistein, also known as genistein, dye isoflavones, is mainly an active ingredient extracted from legumes such as soybeans, clover, pueraria, locust, genistein (gorse), and broad bean root. Genistein is called phytoestrogens. It has a variety of pharmacological effects such as its estrogen-like effect, anti-tumor, anti-diabetic, and prevention of cardiovascular diseases. Genistein has the effects of inducing programmed cell death, improving anti-cancer efficacy, inhibiting angiogenesis, etc. It is a potential cancer chemopreventive agent, and its anti-cancer effect and mechanism have broad application prospects.

CAS 446-72-0 Genistein Herbal Extract Powder For Cardiovascular Diseases 0

CERTIFICATE OF ANALYSIS

Product Name Genistein Batch Number XALC20210319
Botanical Source Sophora Japonica L. Manufacture Date Mar.19,2021
Plant Part Used Fruit Analysis Date Mar.20,2021
Quantity 517kgs Expire Date Mar.25,2023
Item Standard Test Result Test Method
Assay      
Genistein ≥98% ≥98.42% HPLC
Physical&Chemical      
Appearance Off-white fine powder Complies Visual
Odor&Taste Characteristic Characteristic Organoleptic
Particle Size 80mesh 100% Pass 80mesh USP36<786>
Ash ≤2% 0.73% USP36<281>
Loss on Drying ≤2% 1.02% USP36<731>
Heavy Metal      
Pb ≤1ppm 0.45ppm ICP-MS
As ≤1ppm 0.62ppm ICP-MS
Cd ≤1ppm 0.13ppm ICP-MS
Hg ≤0.5ppm 0.005ppm ICP-MS
Microbiological Test      
Total Plate Count ≤1,000cfu/g Complies AOAC
Yeast&Mold ≤100cfu/g Complies AOAC
E. Coli Negative Negative AOAC
Salmonella Negative Negative AOAC
Staphylococcus Negative Negative AOAC
Conclusion
Conform with specification, Non-GMO, Non-irradiation, Allergen Free, TSE/BSE Free.
Storage
Store in cool and dry places. Keep away from strong light and heat.
Packing
By 25kgs/Drum, inner by plastic bag or aluminum foil bag.
Shelf Life
24 months under the above condition, and in it’s original package
 

Pharmacological action of Herbal Extract Powder

1. Genistein and Cardiovascular diseases

Genistein plays a very important role in reducing the incidence of cardiovascular diseases. Low-density lipoprotein cholesterol in the blood is high and easily oxidized, which can cause atherosclerosis. Genistein can effectively reduce cholesterol through antioxidant effects, inhibit the oxidation of low-density lipoprotein cholesterol (LDL), and keep LDL in the blood stay at a low level. It can also improve the abnormal peroxidation status in the body caused by high fat, and relieve the peroxidation damage to the body. Genistein can up-regulate LDL receptors, increase LDL receptor activity, and promote cholesterol clearance. Genistein also has the effects of inhibiting the proliferation of smooth muscle cells and angiogenesis, as well as inhibiting cell adhesion, thereby reducing the incidence of cardiovascular diseases.

 

2. Genistein and Cranial nerves

The latest literature reports that genistein has the effect of promoting cranial nerve regeneration and cerebral coma. Modern medical theory believes that when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur, a series of pathophysiological changes such as ischemia, hypoxia, degeneration, and necrosis of brain tissue cells are closely related to the influx of large amounts of extracellular calcium ions in brain tissue. The overload of calcium ions in brain cells is one of the main causes of brain cell degeneration and necrosis. The latest study found that after changing the route of administration, genistein can pass through the blood-brain barrier, and by affecting the Ca++ receptors on brain cell membranes, it can protect brain cells when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur.

 

3. Genistein and Cancer

Genistein inhibits tyrosine kinase activity and topoisomerase activity through antioxidant effects; reduces tumor angiogenesis through estrogen and anti-estrogen-like effects, and has inhibitory and therapeutic effects on a variety of cancers.

 

4. Genistein and Anti-radiation

Genistein (genistein) is an effective inhibitor of protein tyrosine kinase activity. It also has antioxidant and estrogen-like effects. Landauer et al., working in the laboratory of the American Armed Forces Institute of Radiobiology (AFRRI), confirmed that it is a radioprotective agent, regardless of whether it is injected subcutaneously 24 hours before irradiation, or intragastrically administered 4 days before irradiation or 4 days after irradiation. Genistein can significantly improve the 30-day survival rate of mice receiving a total body radiation dose (9.5Gy) of fatal traumatic brain injury.

 

5. Genistein and Women's Menopause Syndrome

Genistein has weak estrogenic activity and has the effect of estrogen. Studies have shown that women will experience a series of symptoms of menopausal syndrome due to ovarian degeneration and decrease in estrogen in the body during menopause. And taking a quantitative amount of genistein supplements can support the lack of estrogen in the body and plays a role in preventing and reducing women's menopausal syndrome. Experiments suggest that estrogen-like effects may be the main mechanism of genistein to prevent osteoporosis.

 

Product Function of Herbal Extract Powder

1. Prevent Alzheimer's Disease

Alzheimer's disease is currently the most common type of dementia, which is more common in women. Recent studies have shown that the human brain is also a target tissue for estrogen. The hippocampal synaptosomes with memory functions in the brain contain estrogen receptors. The medical profession has confirmed that estrogen levels are closely related to Alzheimer’s disease. Genistein and real estrogen are good for the brain.

 

2. Beauty, anti-aging effect

The estrogen-like effect of Genistein can make women's skin smooth, delicate, tender, elastic and youthful. Women activate the adipose tissue in the breasts by supplementing estrogen, so that free fat is attracted to the breasts, so as to achieve the effect of breast enhancement.

Studies have shown that modern women have early menopause, and long-term supplementation of Genistein can maintain normal levels of estrogen in the body, delay menopause, and achieve the effect of delaying aging.

 

3. Improve menstrual discomfort

Menstrual discomfort is generally related to the unbalanced secretion of estrogen. Long-term supplementation of Genistein can maintain normal levels of estrogen in the body and achieve the purpose of improving menstrual discomfort.

 

4. Improve the quality of sexual life

The estrogen-like effect of Genistein can increase the maturity of female vaginal epithelial cells and increase vaginal muscle elasticity, thereby improving the quality of sexual life.

 

5. Reduce cholesterol

Cardiovascular disease (CHD) is a multifactorial disease, in which cholesterol (Ch) plays an important role. A large-scale study of 5,000 people conducted in Japan showed that soy isoflavones have the effect of lowering cholesterol and inhibiting thrombosis. A study on young women in the United Kingdom showed the dose-effect relationship of isoflavones. Isoflavones above 45 mg per day can reduce total Ch and LDL-Ch levels by 10% for 30 consecutive days, while 23 mg isoflavones has no effect.

 

6. Regulate blood lipids to prevent cardiovascular disease

Genistein can reduce the body's susceptibility to serum LDL oxidation. After serum LDL lipoprotein is oxidized, it activates the phagocytosis of macrophages in the human body, and develops into foam cells in the arterial wall, and then forms atheromatous plaques. Genistein not only have antioxidant effects on their own, but can also induce the increase of antioxidant enzyme activity, improve the antioxidant capacity of serum LDL, prevent the formation of atherosclerotic plaques on the arterial wall and prevent atherosclerosis. At the same time, it increases the compliance of arteries and expands blood vessels. Genistein also inhibit the atherosclerosis process by affecting tyrosine kinases, including foam cells, fatty streaks, hyperplasia, fibrous plaque infiltration, rupture and ulcers, keeping the heart arteries and vessels unobstructed and preventing cardiovascular diseases happened.

 

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