Le-nutra Sophora Japonica Extract Meletin and Sophretin powder CAS#117-39-5 Herbal Extract Powder

Base information of Product

Introduction of Product

Sophora Japonica Extract is a kind of flavonols widely distributed in the plant kingdom and has a variety of biological activities. Quercetin can fight free radicals, complex or capture free radicals to prevent the body lipid peroxidation reaction; Can directly inhibit the tumor, effectively play the role of cancer prevention and anticancer; It also has strong biological activity in antibacterial, anti-inflammatory, anti-allergic and preventing diabetic complications. In addition, quercetin also has the effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, lowering blood lipid, dilating coronary artery and increasing coronary blood flow. It also has an adjutant therapeutic effect on patients with coronary heart disease and hypertension. Quercetin is non-toxic, therefore, it is of great significance for the treatment and prevention of cancer, aging and cardiovascular diseases, and has great development value.

Function and Application of Product

Sophora Japonica Extract as a widely exists in the nature of natural flavonoids, gain in-depth research, at present has found that it has multiple biological activity, such as antioxidant, anti-viral, anti-inflammatory effects, in the cell and animal experiments can be used to treat liver, heart, spleen, lung, kidney, bone disease, nervous system diseases, etc.

1. Antioxidant effect

Quercetin is a natural chelating agent that can chelate iron in the body, reducing iron overload in the body and reducing oxidative damage caused by iron overload. 

Quercetin has antioxidant, free radical scavenging, inhibiting lipid peroxidation and other functions, which can protect cardiovascular health, and also shows a good effect in anti-cancer. However, the data from these studies are from cytological or animal studies, and more needs to be done to determine whether direct use in humans is effective.

2. Antitumor activity

In the aspect of anti-cancer, many studies have shown that quercetin has inhibitory effect on various cancer cells. In terms of the specific mechanism of action, quercetin has a variety of biological effects, inhibiting various enzymes in cancer cells involved in cell proliferation and signal transduction pathways.

3. Heart protection

Quercetin can reduce blood pressure, enhance the resistance of capillaries, reduce the fragility of capillaries, reduce blood lipids, dilate coronary arteries, increase coronary blood flow and so on. It also has an adjunctive therapeutic effect on patients with coronary heart disease and hypertension.

Quercetin can effectively reduce the oxidative damage induced by H2O2 and inhibit the apoptosis of myocardial cells. The treatment of quercetin significantly reduced the number of premature ventricular beats, suggesting that quercetin has a significant cardiac protective effect on coronary heart disease.

4. Antiviral activity

Quercetin significantly reduced the replication rate of HCV and was found to reduce the infectivity of quercetin treated virus particles by 65%, suggesting that quercetin affected the integrity of the virus. Furthermore, molecular level experiments confirmed that quercetin can exert antiviral effects by preventing HCV up-regulation of diacylglyceryl transferase and the typical localization of HCV core protein on the surface of lipid droplets.

The preparation methods of Quercetin

1. Natural extraction separation

Because the content of Sophora Japonica Extract in plants is only a few to a few parts per thousand, and the extraction and separation of quercetin is difficult and the cost is high, the direct extraction of quercetin from plants is not practical in production. However, the extraction and separation technology of quercetin should be used in the analysis and identification of flavonoids or in the preparation of analytical pure samples. 

2. The acid hydrolysis

The rutin of Sophora Japonica Extract is widely distributed in nature with high content, for example, the content in Sophora japonica is more than 20%. It is feasible to extract rutin from Sophora sophorae and produce quercetin after acid hydrolysis. 

The main extraction methods of rutin include alkali extraction and acid precipitation, organic solvent extraction and impregnation, among which alkali extraction and acid precipitation is the most practical method. 0.05%NaOH solution was selected to boil for 20 min, filtered while hot, and extracted by the same method for 4 times to obtain the alkaline solution of rutin. Acid was added to precipitate it out. After filtration, acid was added to hydrolyze it to obtain quercetin, which was insoluble in water. 

3. Enzyme catalysis

The rutin was hydrolyzed by enzymatic hydrolysis to prepare Sophora Japonica Extract monomer with less content in plants. The operation is simple and safe, the whole process is economical and applicable, the yield is large, and it is suitable for industrial production. The purity of the product >90% can meet the needs of food and clinical application. Therefore, enzymatic transformation is undoubtedly a promising preparation method.