Product Description
Procuct Information of Herbal Extract Powder
Name Kaempherol
Molecular weight 286.23
Molecular formula C15H10O6
Melting point 276°C-278°C
Solubility Slightly soluble in water, soluble in hot ethanol, ether and alkali.
Procuct Introduction of Herbal Extract Powder
Kaempferol is one of the many flavonoids found in foods alongside others like luteolin and quercetin. It is showing promise in and of itself in being an anti-obesity agent and anti-cancer agent.
Kaempferol, as a polyphenol, is present in many compounds. Common sources include:
Apples
Citris Fruits
Grapes and red wine
Onions and leeks
Tea (camellia sinensis)
Ginkgo Bilboa and St.Johns Wort
Nymphaea odorata
Alpinia officinarum hance, or Galangal Extract
Hedyotis verticillata (Source of kaempferitrin, kaempferol's rhamnoside sugar form)
Red beans and pinto beans (husk)[3] generally the species of bean Phaseolus Vulgaris.
Certificate of Analysis
| Product Name |
Kaempferol |
| Botanical Source |
Sophora Japonica L. |
| Plant Part Used |
Fruit |
| Quantity |
463kgs |
| Item |
Standard |
Test Result |
Test Method |
| Assay |
| Kaempferol |
≥98% |
99.32% |
HPLC |
| Physical&Chemical |
| Appearance |
Yellow fine Powder |
Complies |
Visual |
| Odor&Taste |
Characteristic |
Characteristic |
Organoleptic |
| Particle Size |
80mesh |
100% Pas 80mesh |
USP<786> |
| Ash |
≤2% |
0.82% |
USP<281> |
| Loss on Drying |
≤2% |
1.04% |
USP<731> |
| Heavy Metal |
| Pb |
≤1ppm |
0.45ppm |
ICP-MS |
| As |
≤1ppm |
0.62ppm |
ICP-MS |
| Cd |
≤1ppm |
0.13ppm |
ICP-MS |
| Hg |
≤0.5ppm |
0.005ppm |
ICP-MS |
| Microbiological Test |
| Total Plate Count |
≤1,000cfu/g |
Complies |
AOAC |
| Yeast&Mold |
≤100cfu/g |
Complies |
AOAC |
| E.Coli |
Negative |
Negative |
AOAC |
| Salmonella |
Negative |
Negative |
AOAC |
| Staphylococcus |
Negative |
Negative |
AOAC |
| Conclusion |
| Conform with specification, Non-GMO, Non-irradiation, Allergen, TSE/BSE Free. |
| Storage |
| Store in cool and dry places. Keep away from strong light and heat. |
| Packing |
| By 25kgs/Drum, inner by plastic bag or aluminum foil bag. |
| Shelf Life |
| 24 months under the above condition, and in it’s original package. |
Pharmacological action of Herbal Extract Powder
Glucose Uptake
Kaempferol, possibly through the metabolite kaempferol 3-neohesperidoside, may increase glucose uptake into myocytes via processes mediated by phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) pathways and has been suspected as being as potent as insulin in this regard.
Osteoblasts
Similar to myricetin, Kaempferol prevents against oxidation in in vitro bone cells and may exert anti-osteoporotic effects.
Adipogenesis
Kaempferol's inhibitory activity on Fatty Acid Synthase(FASN), the sole enzyme responsible for de novo lipogenesis, is via acting as an inhibitor of the FASN cascade, which uses the two substrate malonyl-CoA and acetyl-Coa along with NAPDH to ultimately produce palmitate.[16] Out of tested polyphenols, Kaempferol's inhibition of FASN was more potent than that of Green Tea Catechins, Apigenin and Taxifolin.
Kaempferol (as well as Quercetin) are able to inhibit PPARγ activation of adipogenesis by rosiglitazone and other endogenous ligands by having high affinity to the receptor but low potency to activate it.
Over the long term, Kaempferol may reduce adipocyte formation by causing its stem cell (bone marrow cells) to favor osteogenesis (bone forming) rather than fat cell forming.
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