Anti Impotence Men Health Supplements Pharmaceutical Grade Raw Sildenafil Powder

Product Description

Factory supply sildenafil powder pharmaceutical grade raw sildenafil Sildenafil price

Product Introduction

99% Sildenafil was the first oral anti-impotence drug to be marketed for the first time in the United States in April 1998. Many studies have proved that nitric oxide is the main mediator of corpus cavernosa smooth muscle relaxation and erection. Sildenafil is a selective inhibitor of phosphodiesterase (PDE) V, which can enhance the physiological response of penile erection caused by the release of NO under sexual stimulation. NO is released from nerve endings and endothelial cells and binds to receptors on the smooth muscle of the cavernous body to activate intracellular soluble guanylate cyclase, which, with the participation of Mn2+, promotes guanosine triphosphate (GTP) to cyclic monophosphate Guanosine (cGMP), cGMP activate protein kinase G (PKG) and a small part of protein kinase A (PKA). The activated PKG and PKA reduce the intracellular free Ca2+ level by activating the Ca2+ pump, which leads to relaxation of the corpus cavernosum smooth muscle and arterial blood. Inflow, the penis is congested, hard, and erect. PDE V exists in human cavernous tissue and vascular smooth muscle, which can hydrolyze cGMP into GMP and block the NO-cGMP pathway that makes penile erection. Sildenafil is a selective inhibitor of PDE V, which can prevent the degradation of cGMP, thereby enhancing the penile erectile response to sexual excitement.

Product Description

CAS: 139755-83-2

EINECS:252-082-4

Specification:99%

Apperance :White Powder

MF :C22H30N6O4S

MW :474.58

TTesting Method: HPLC

Shelf Life :24 Months

COA

Function

1. 99% Sildenafil can cope with the problem of erectile dysfunction. Sildenafil increases the level of cyclic guanosine phosphate (cGMP) in the penile cavernous body by inhibiting phosphodiesterase 5 (PDE5), relaxes the smooth muscle of the cavernous body, and blood flows into the cavernous body. It can improve the erectile response caused by sexual stimulation, and the drug effect can last for 4 hours.

2. 99% Sildenafil has a certain effect on pulmonary hypertension. The US FDA has approved sildenafil for the treatment of pulmonary hypertension. For hypoxic pulmonary hypertension associated with high altitude, sildenafil has a certain effect.

3. 99% Sildenafil can improve female infertility, uterine artery and ovarian artery blood supply disorder, which is one of the causes of infertility in women. Sildenafil can expand uterine artery blood flow and ovarian artery blood flow, improve the development of the endometrium, increase the success rate of pregnancy, and reduce the abortion rate of infertile patients with thin endometrium.

4. 99% Sildenafil can improve lower urinary tract symptoms. The occurrence of benign prostatic hyperplasia (BPH) is closely related to sexual dysfunction. Sildenafil can inhibit the proliferation of interstitial cells in the prostate, relax the smooth muscles of the prostate, bladder, and urethra, and improve the symptoms of the lower urinary tract. It should be reminded that if you take α-blockers (such as doxazosin) and sildenafil at the same time, it can cause orthostatic hypotension.

Sildenafil interaction

-99% Sildenafil and food. Oral sildenafil on an empty stomach can reach the peak concentration in 0.5 to 2 hours; when taken with a high-fat diet, the peak time of sildenafil is delayed by 1 hour, and the peak concentration is reduced by about 30% . Grapefruit juice can increase the bioavailability of sildenafil and increase the blood concentration of sildenafil. Avoid taking it as much as possible. Sildenafil does not enhance the antihypertensive effect of alcohol, but both can cause hypotension.

-99% Sildenafil and antiangina drugs.sildenafil and nitroglycerin, isosorbide dinitrate, isosorbide mononitrate and other antiangina drugs can cause fatal hypotension. Within 24 hours (at least) after taking sildenafil, organic nitrates are prohibited. Studies have found that Suxiao Jiuxin Pills have a certain antihypertensive effect. Those taking sildenafil should also use Suxiao Jiuxin Pills with caution.

-99% Sildenafil and antihypertensive drugs. Sildenafil alone can reduce blood pressure by about 10/5mmHg. For patients who are taking antihypertensive drugs, sildenafil may cause symptoms of hypotension.

-99% Sildenafil and Erythromycin. Sildenafil is mainly metabolized through CYP3A4 (primary pathway) and CYP2C9 (secondary pathway), with an elimination half-life of about 4 hours.

CYP3A4 inhibitors: erythromycin, clarithromycin, cimetidine, itraconazole, fluconazole, etc., inhibit the metabolism of sildenafil and increase the blood concentration of sildenafil, which can cause severe hypotension .

Dosage

99% Sildenafil For most patients, the recommended dose is 50 mg, taken about 1 hour before sexual activity; however, it can be taken at any time within 0.5 to 4 hours before sexual activity. Based on efficacy and tolerability, the dose can be increased to 100 mg (the maximum recommended dose) or reduced to 25 mg. Take it up to 1 time a day.

The following factors are related to the increase in plasma sildenafil level (AUC): age 65 years or older (40% increase), liver damage (such as cirrhosis, 80% increase), severe renal damage (creatinine clearance rate <30ml/min, Increased by 100%), while taking strong cytochrome P450 3A4 inhibitors (ketoconazole, itraconazole increased by 200%), erythromycin increased by 182%, saquinavir increased by 210%. Since higher plasma levels may increase the efficacy and the incidence of adverse events at the same time, the starting dose for these patients is preferably 25 mg.

Studies have shown that the HIV protease inhibitor Ritonavir can significantly increase the blood level of sildenafil (AUC increased by 11 times). In view of this, it is recommended that patients taking Ritonavir do not exceed 25 mg at most every 48 hours.