Sexual Enhancement Sildenafil Citrate Powder

Product Description

sildenafil citrate powder for sexual enhancement,sildenafil citrare,high quality sildenafil

Product Introduction

Sildenafil is a drug for the treatment of male erectile dysfunction that was accidentally invented during the development of drugs for the treatment of cardiovascular diseases. It is the citrate of sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5) specific to cyclic guanosine phosphate (cGMP), which can make patients with erectile dysfunction naturally respond to sexual stimulation Erectile reaction.

Product Description

CAS: 139755-83-2

EINECS:252-082-4

Apperance :White Powder

MF :C22H30N6O4S

MW :474.58

TTesting Method: HPLC

Shelf Life :24 Months

COA

Pharmacological action

Sildenafil is a selective inhibitor of cyclic guanosine phosphate (cGMP) specific type 5 phosphodiesterase (PDE5), and is an oral drug for the treatment of ED. The physiological mechanism of normal penile erection involves the release of nitric oxide (NO) in the body during sexual stimulation. Nitric oxide activates guanylate cyclase in the smooth muscle cells of the corpus cavernosum, leading to an increase in the level of cGMP, causing the smooth muscles in the cavernous body to relax, the cavernous sinuses are dilated, and blood flows into the penis to make the penis erect. Patients with erectile dysfunction are mainly due to relaxation of the smooth muscle of the corpus cavernosum. Sildenafil has no direct relaxation effect on the isolated human corpus cavernosum, but it can enhance the effect of nitric oxide by inhibiting the decomposition of cGMP by PDE5 in the corpus cavernosum. When sexual stimulation causes local nitric oxide release, sildenafil inhibits PDE5, increases cGMP levels in the cavernous body, relaxes the smooth muscle of the cavernous body, and blood flows into the cavernous body. Studies have shown that the erectile response increases with the increase of dose and plasma concentration, and the drug effect can last for 4 hours. In vitro experiments show that sildenafil has a high selectivity to PDE5, which is more than 80 times more selective than PDE1, more than 700 times more than PDE2 and PDE4, and 4000 times more than PDE3. Since PDE3 is related to the control of myocardial contractility, and there is no PDE5 in the myocardium, sildenafil has no positive inotropic effect and does not directly affect myocardial contractility. However, sildenafil can relax the blood vessels of the systemic circulation, and when high-dose (100mg) is taken orally, it can cause a drop in supine blood pressure [average maximum drop 1.12/0.73kPa (8.4/5.5mmHg)], and the blood pressure drop is most obvious 1～2h after taking the drug Therefore, sexual activity may induce cardiac events at the peak blood concentration. The selective effect of sildenafil on PDE5 is only 10 times that of PDE6, and PDE6 is an enzyme that exists in the retina, so sildenafil may cause abnormal color vision at high doses or high blood concentration. In addition to human cavernous smooth muscle, low concentrations of PDE5 are also found in platelets, blood vessels, visceral smooth muscle, and skeletal muscle. Sildenafil may enhance anti-platelet aggregation (in vitro experiment), inhibit platelet thrombosis (in vivo experiment), and relax surrounding blood vessels (in vivo experiment) by inhibiting PDE5 in these tissues.

Taboo

1. Those who are allergic to sildenafil.

2. Those who are using nitroglycerin, sodium nitroprusside or other organic nitrates